BAIT
YWHAG
14-3-3GAMMA, PPP1R170
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
GO Process (11)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- apoptotic process [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane organization [TAS]
- mitotic cell cycle [TAS]
- negative regulation of protein kinase activity [NAS]
- negative regulation of protein serine/threonine kinase activity [NAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of neuron differentiation [IMP]
- regulation of signal transduction [NAS]
- regulation of synaptic plasticity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DLC1
ARHGAP7, HP, STARD12, p122-RhoGAP
DLC1 Rho GTPase activating protein
GO Process (19)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- actin cytoskeleton organization [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic process [IDA]
- focal adhesion assembly [ISS]
- forebrain development [ISS]
- heart morphogenesis [ISS]
- hindbrain morphogenesis [ISS]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cell migration [IDA, IMP]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of stress fiber assembly [IDA]
- neural tube closure [ISS]
- positive regulation of Rho GTPase activity [IDA, IMP]
- positive regulation of execution phase of apoptosis [IDA]
- positive regulation of protein dephosphorylation [IDA]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cell shape [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A central chaperone-like role for 14-3-3 proteins in human cells.
14-3-3 proteins are highly conserved regulatory proteins that interact with hundreds of structurally diverse clients and act as central hubs of signaling networks. However, how 14-3-3 paralogs differ in specificity and how they regulate client protein function are not known for most clients. Here, we map the interactomes of all human 14-3-3 paralogs and systematically characterize the effect of disrupting ... [more]
Mol Cell Mar. 16, 2023; 83(6);974-993.e15 [Pubmed: 36931259]
Throughput
- High Throughput
Additional Notes
- Interaction confidence score is 1 minus the Bayesian False Discovery Rate (BFDR) calculated from SAINT analysis. Interaction cutoff is BFDR <= 0.01 (confidence score >= 0.99)
- Vehicle control condition
Curated By
- BioGRID