BAIT
CBLL1
HAKAI, RNF188
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
GO Process (5)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DDX3X
CAP-Rf, DBX, DDX14, DDX3, HLP2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
GO Process (29)
GO Function (14)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IDA, TAS]
- DNA duplex unwinding [IDA]
- RNA secondary structure unwinding [IDA]
- cellular response to arsenic-containing substance [IDA]
- cellular response to osmotic stress [IDA]
- chromosome segregation [IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- innate immune response [IMP]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway [IMP]
- mature ribosome assembly [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of protein complex assembly [IDA]
- negative regulation of translation [IMP]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of chemokine (C-C motif) ligand 5 production [TAS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of interferon-beta production [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of translation [IDA]
- positive regulation of translational initiation [IMP]
- positive regulation of viral genome replication [IMP]
- response to virus [IDA]
- stress granule assembly [IDA]
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [IDA]
- ATP-dependent RNA helicase activity [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- RNA binding [IDA]
- RNA stem-loop binding [IDA]
- eukaryotic initiation factor 4E binding [IDA]
- mRNA 5'-UTR binding [IDA]
- poly(A) RNA binding [IDA]
- poly(A) binding [IDA]
- protein binding [IPI]
- ribosomal small subunit binding [IDA]
- transcription factor binding [IDA]
- translation initiation factor binding [IDA]
- ATP-dependent DNA helicase activity [IDA]
- ATP-dependent RNA helicase activity [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- RNA binding [IDA]
- RNA stem-loop binding [IDA]
- eukaryotic initiation factor 4E binding [IDA]
- mRNA 5'-UTR binding [IDA]
- poly(A) RNA binding [IDA]
- poly(A) binding [IDA]
- protein binding [IPI]
- ribosomal small subunit binding [IDA]
- transcription factor binding [IDA]
- translation initiation factor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.
The E3 ubiquitin-ligases are important for cellular protein homeostasis and their deregulation is implicated in cancer. The E3 ubiquitin-ligase Hakai is involved in tumour progression and metastasis, through the regulation of the tumour suppressor E-cadherin. Hakai is overexpressed in colon cancer, however, the implication in colitis-associated cancer is unknown. Here, we investigated the potential role of Hakai in intestinal inflammation ... [more]
Sci Rep Oct. 20, 2022; 12(1);17571 [Pubmed: 36266428]
Throughput
- High Throughput
Curated By
- BioGRID