BAIT
YWHAH
YWHA1, LL22NC03-44A4.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
GO Process (15)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- apoptotic process [TAS]
- glucocorticoid catabolic process [IDA]
- glucocorticoid receptor signaling pathway [IDA]
- intracellular protein transport [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane depolarization during action potential [IDA]
- membrane organization [TAS]
- negative regulation of dendrite morphogenesis [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of neuron differentiation [ISS]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of sodium ion transport [IDA]
- regulation of synaptic plasticity [ISS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAPGEF2
CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP
Rap guanine nucleotide exchange factor (GEF) 2
GO Process (35)
GO Function (12)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [NAS]
- Rap protein signal transduction [IMP]
- adenylate cyclase-activating adrenergic receptor signaling pathway [IDA]
- blood vessel development [ISS]
- brain-derived neurotrophic factor receptor signaling pathway [ISS]
- cAMP-mediated signaling [IDA, NAS]
- cellular response to cAMP [IDA]
- cellular response to cGMP [IDA]
- cellular response to nerve growth factor stimulus [ISS]
- establishment of endothelial barrier [IMP]
- forebrain neuron development [ISS]
- intracellular signal transduction [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of dendrite morphogenesis [IDA]
- negative regulation of melanin biosynthetic process [ISS]
- nerve growth factor signaling pathway [ISS]
- neuron migration [ISS]
- neuron projection development [IDA]
- neuropeptide signaling pathway [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of Rap GTPase activity [IDA, IMP]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of dendritic cell apoptotic process [IDA]
- positive regulation of neuron migration [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of protein binding [ISS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of vasculogenesis [ISS]
- regulation of cell junction assembly [IMP]
- regulation of synaptic plasticity [ISS]
- small GTPase mediated signal transduction [TAS]
- ventricular system development [ISS]
Gene Ontology Molecular Function- PDZ domain binding [IDA]
- Rap GTPase activator activity [IDA]
- Rap guanyl-nucleotide exchange factor activity [IDA, IMP]
- Ras guanyl-nucleotide exchange factor activity [IDA]
- WW domain binding [IDA]
- beta-1 adrenergic receptor binding [IDA]
- cAMP binding [IDA]
- cGMP binding [IDA]
- calcium ion binding [NAS]
- diacylglycerol binding [NAS]
- protein binding [IPI]
- signal transducer activity [TAS]
- PDZ domain binding [IDA]
- Rap GTPase activator activity [IDA]
- Rap guanyl-nucleotide exchange factor activity [IDA, IMP]
- Ras guanyl-nucleotide exchange factor activity [IDA]
- WW domain binding [IDA]
- beta-1 adrenergic receptor binding [IDA]
- cAMP binding [IDA]
- cGMP binding [IDA]
- calcium ion binding [NAS]
- diacylglycerol binding [NAS]
- protein binding [IPI]
- signal transducer activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A central chaperone-like role for 14-3-3 proteins in human cells.
14-3-3 proteins are highly conserved regulatory proteins that interact with hundreds of structurally diverse clients and act as central hubs of signaling networks. However, how 14-3-3 paralogs differ in specificity and how they regulate client protein function are not known for most clients. Here, we map the interactomes of all human 14-3-3 paralogs and systematically characterize the effect of disrupting ... [more]
Mol Cell Mar. 16, 2023; 83(6);974-993.e15 [Pubmed: 36931259]
Throughput
- High Throughput
Additional Notes
- Interaction confidence score is 1 minus the Bayesian False Discovery Rate (BFDR) calculated from SAINT analysis. Interaction cutoff is BFDR <= 0.01 (confidence score >= 0.99)
- Interaction confidence score is 1 minus the Bayesian False Discovery Rate (BFDR) calculated from SAINT analysis. Interaction cutoff is BFDR <= 0.01 (confidence score >= 0.99)
- Vehicle control condition
- okadaic acid (serine/threonine phosphatases inhibition) condition
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| YWHAH RAPGEF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3376221 |
Curated By
- BioGRID