BAIT
YWHAE
14-3-3E, HEL2, KCIP-1, MDCR, MDS
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
GO Process (18)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- hippo signaling [TAS]
- intracellular signal transduction [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane organization [TAS]
- membrane repolarization during cardiac muscle cell action potential [IC]
- mitotic cell cycle [TAS]
- negative regulation of peptidyl-serine dephosphorylation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of heart rate by cardiac conduction [IC]
- regulation of heart rate by hormone [NAS]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- substantia nigra development [IEP]
Gene Ontology Molecular Function- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
GSK3A
glycogen synthase kinase 3 alpha
GO Process (33)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cardiac left ventricle morphogenesis [ISS]
- cellular protein metabolic process [TAS]
- cellular response to insulin stimulus [IMP]
- cellular response to interleukin-3 [ISS]
- endoplasmic reticulum unfolded protein response [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [ISS]
- negative regulation of TOR signaling [ISS]
- negative regulation of UDP-glucose catabolic process [IC]
- negative regulation of canonical Wnt signaling pathway [TAS]
- negative regulation of cell growth involved in cardiac muscle cell development [ISS]
- negative regulation of glucose import [IMP]
- negative regulation of glycogen (starch) synthase activity [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of transferase activity [IMP]
- negative regulation of type B pancreatic cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of adrenergic receptor signaling pathway [ISS]
- positive regulation of cAMP biosynthetic process [ISS]
- positive regulation of glycogen (starch) synthase activity [ISS]
- positive regulation of heart contraction [ISS]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISS]
- positive regulation of protein catabolic process [NAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA]
- regulation of systemic arterial blood pressure [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A central chaperone-like role for 14-3-3 proteins in human cells.
14-3-3 proteins are highly conserved regulatory proteins that interact with hundreds of structurally diverse clients and act as central hubs of signaling networks. However, how 14-3-3 paralogs differ in specificity and how they regulate client protein function are not known for most clients. Here, we map the interactomes of all human 14-3-3 paralogs and systematically characterize the effect of disrupting ... [more]
Mol Cell Mar. 16, 2023; 83(6);974-993.e15 [Pubmed: 36931259]
Throughput
- High Throughput
Additional Notes
- Interaction confidence score is 1 minus the Bayesian False Discovery Rate (BFDR) calculated from SAINT analysis. Interaction cutoff is BFDR <= 0.01 (confidence score >= 0.99)
- okadaic acid (serine/threonine phosphatases inhibition) condition
Curated By
- BioGRID