YWHAQ
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ALS2
Gene Ontology Biological Process
- endosome organization [IGI, NAS]
- neuron projection morphogenesis [IDA]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of Rac protein signal transduction [IC]
- positive regulation of Ran GTPase activity [NAS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein serine/threonine kinase activity [IDA]
- regulation of endosome size [IEP]
Gene Ontology Molecular Function- Rab GTPase binding [IDA, NAS]
- Rab guanyl-nucleotide exchange factor activity [IDA]
- Rac guanyl-nucleotide exchange factor activity [IDA]
- Ran guanyl-nucleotide exchange factor activity [NAS]
- guanyl-nucleotide exchange factor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein serine/threonine kinase activator activity [IDA]
- Rab GTPase binding [IDA, NAS]
- Rab guanyl-nucleotide exchange factor activity [IDA]
- Rac guanyl-nucleotide exchange factor activity [IDA]
- Ran guanyl-nucleotide exchange factor activity [NAS]
- guanyl-nucleotide exchange factor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein serine/threonine kinase activator activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A central chaperone-like role for 14-3-3 proteins in human cells.
14-3-3 proteins are highly conserved regulatory proteins that interact with hundreds of structurally diverse clients and act as central hubs of signaling networks. However, how 14-3-3 paralogs differ in specificity and how they regulate client protein function are not known for most clients. Here, we map the interactomes of all human 14-3-3 paralogs and systematically characterize the effect of disrupting ... [more]
Throughput
- High Throughput
Additional Notes
- Interaction confidence score is 1 minus the Bayesian False Discovery Rate (BFDR) calculated from SAINT analysis. Interaction cutoff is BFDR <= 0.01 (confidence score >= 0.99)
- okadaic acid (serine/threonine phosphatases inhibition) condition
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
YWHAQ ALS2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9897 | BioGRID | 3128693 | |
YWHAQ ALS2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3236516 |
Curated By
- BioGRID