BAIT
YWHAQ
14-3-3, 1C5, HS1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
GO Process (6)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
USP22
USP3L
ubiquitin specific peptidase 22
GO Process (10)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- chromatin organization [TAS]
- embryo development [NAS]
- histone H4 acetylation [IDA]
- histone deubiquitination [IDA]
- histone ubiquitination [IDA]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function- H4 histone acetyltransferase activity [IDA]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, IMP]
- H4 histone acetyltransferase activity [IDA]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, IMP]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A central chaperone-like role for 14-3-3 proteins in human cells.
14-3-3 proteins are highly conserved regulatory proteins that interact with hundreds of structurally diverse clients and act as central hubs of signaling networks. However, how 14-3-3 paralogs differ in specificity and how they regulate client protein function are not known for most clients. Here, we map the interactomes of all human 14-3-3 paralogs and systematically characterize the effect of disrupting ... [more]
Mol Cell Mar. 16, 2023; 83(6);974-993.e15 [Pubmed: 36931259]
Throughput
- High Throughput
Additional Notes
- Interaction confidence score is 1 minus the Bayesian False Discovery Rate (BFDR) calculated from SAINT analysis. Interaction cutoff is BFDR <= 0.01 (confidence score >= 0.99)
- okadaic acid (serine/threonine phosphatases inhibition) condition
Curated By
- BioGRID