BAIT
USP7
HAUSP, TEF1
ubiquitin specific peptidase 7 (herpes virus-associated)
GO Process (8)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- histone deubiquitination [IBA]
- maintenance of DNA methylation [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, IMP]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of sequence-specific DNA binding transcription factor activity [IDA]
- transcription-coupled nucleotide-excision repair [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
NGEF
ARHGEF27, EPHEXIN
neuronal guanine nucleotide exchange factor
GO Process (8)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- ephrin receptor signaling pathway [ISS]
- negative regulation of dendritic spine morphogenesis [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of GTPase activity [ISS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags from specific target protein substrates in order to alter their degradation rate, sub-cellular localization, interaction, and activity. The induction of apoptosis upon USP7 inhibition is well established in cancer containing wild type p53, which operates through the 'USP7-Mdm2-p53' axis. However, in cancers without functional p53, USP7-dependent ... [more]
Oncogene Nov. 01, 2022; 41(47);5061-5075 [Pubmed: 36243803]
Throughput
- High Throughput
Curated By
- BioGRID