BAIT
USP7
HAUSP, TEF1
ubiquitin specific peptidase 7 (herpes virus-associated)
GO Process (8)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- histone deubiquitination [IBA]
- maintenance of DNA methylation [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, IMP]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of sequence-specific DNA binding transcription factor activity [IDA]
- transcription-coupled nucleotide-excision repair [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
EEA1
MST105, MSTP105, ZFYVE2
early endosome antigen 1
GO Process (4)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags from specific target protein substrates in order to alter their degradation rate, sub-cellular localization, interaction, and activity. The induction of apoptosis upon USP7 inhibition is well established in cancer containing wild type p53, which operates through the 'USP7-Mdm2-p53' axis. However, in cancers without functional p53, USP7-dependent ... [more]
Oncogene Nov. 01, 2022; 41(47);5061-5075 [Pubmed: 36243803]
Throughput
- High Throughput
Curated By
- BioGRID