Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

Saha G, Sarkar S, Mohanta PS, Kumar K, Chakrabarti S, Basu M, Ghosh MK

Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags from specific target protein substrates in order to alter their degradation rate, sub-cellular localization, interaction, and activity. The induction of apoptosis upon USP7 inhibition is well established in cancer containing wild type p53, which operates through the 'USP7-Mdm2-p53' axis. However, in cancers without functional p53, USP7-dependent ... [more]

Oncogene Nov. 01, 2022; 41(47);5061-5075 [Pubmed: 36243803]

Throughput

  • High Throughput

Curated By

  • BioGRID