BAIT
YBR063C
Putative protein of unknown function; YBR063C is not an essential gene
GO Process (0)
GO Function (0)
GO Component (0)
Saccharomyces cerevisiae (S288c)
PREY
RTT109
KIM2, REM50, H3 histone acetyltransferase RTT109, KAT11, L000003932, YLL002W
Histone acetyltransferase; critical for cell survival in the presence of DNA damage during S phase; prevents hyper-amplification of rDNA; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p
GO Process (6)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- histone acetylation [IDA, IGI, IMP]
- maintenance of rDNA [IGI]
- negative regulation of transposition, RNA-mediated [IMP]
- regulation of transcription from RNA polymerase II promoter in response to stress [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels.
Mitochondrial functions are tightly regulated by nuclear activity, requiring extensive communication between these organelles. One way by which organelles can communicate is through contact sites, areas of close apposition held together by tethering molecules. While many contacts have been characterized in yeast, the contact between the nucleus and mitochondria was not previously identified. Using fluorescence and electron microscopy in S. ... [more]
J Cell Biol Nov. 01, 2021; 220(11); [Pubmed: 34694322]
Throughput
- High Throughput
Ontology Terms
- mitochondrial distribution (APO:0000297) [mitochondrial distribution (APO:0000297)]
Curated By
- BioGRID