BAIT
SFN
YWHAS
stratifin
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [TAS]
- establishment of skin barrier [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- membrane organization [TAS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of protein kinase activity [TAS]
- negative regulation of protein serine/threonine kinase activity [TAS]
- positive regulation of epidermal cell differentiation [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of epidermal cell division [ISS]
- release of cytochrome c from mitochondria [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SRGAP2
ARHGAP34, FNBP2, SRGAP2A, SRGAP3, RP11-312O7.2
SLIT-ROBO Rho GTPase activating protein 2
GO Process (14)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- actin filament severing [IDA]
- axon guidance [TAS]
- cell proliferation [IMP]
- dendritic spine development [IDA]
- extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [ISS]
- filopodium assembly [IDA]
- lamellipodium assembly involved in ameboidal cell migration [IMP]
- negative regulation of cell death [IMP]
- negative regulation of neuron migration [IDA]
- neuron projection morphogenesis [ISS]
- positive regulation of Rac GTPase activity [IDA, IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- substrate adhesion-dependent cell spreading [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A central chaperone-like role for 14-3-3 proteins in human cells.
14-3-3 proteins are highly conserved regulatory proteins that interact with hundreds of structurally diverse clients and act as central hubs of signaling networks. However, how 14-3-3 paralogs differ in specificity and how they regulate client protein function are not known for most clients. Here, we map the interactomes of all human 14-3-3 paralogs and systematically characterize the effect of disrupting ... [more]
Mol Cell Mar. 16, 2023; 83(6);974-993.e15 [Pubmed: 36931259]
Throughput
- High Throughput
Additional Notes
- BioID
- Interaction confidence score is 1 minus the Bayesian False Discovery Rate (BFDR) calculated from SAINT analysis. Interaction cutoff is BFDR <= 0.01 (confidence score >= 0.99)
- Vehicle control condition
Curated By
- BioGRID