BAIT
YWHAQ
14-3-3, 1C5, HS1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
GO Process (6)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PVRL2
CD112, HVEB, PRR2, PVRR2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
GO Process (16)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- adherens junction organization [TAS]
- adhesion of symbiont to host [IDA]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- coreceptor-mediated virion attachment to host cell [IDA]
- fusion of virus membrane with host plasma membrane [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- positive regulation of immunoglobulin mediated immune response [IMP]
- positive regulation of mast cell activation [IMP]
- positive regulation of natural killer cell mediated cytotoxicity [IMP]
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [IMP]
- regulation of immune response [TAS]
- signal transduction [TAS]
- spermatid development [ISS]
- susceptibility to T cell mediated cytotoxicity [IDA]
- susceptibility to natural killer cell mediated cytotoxicity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A central chaperone-like role for 14-3-3 proteins in human cells.
14-3-3 proteins are highly conserved regulatory proteins that interact with hundreds of structurally diverse clients and act as central hubs of signaling networks. However, how 14-3-3 paralogs differ in specificity and how they regulate client protein function are not known for most clients. Here, we map the interactomes of all human 14-3-3 paralogs and systematically characterize the effect of disrupting ... [more]
Mol Cell Mar. 16, 2023; 83(6);974-993.e15 [Pubmed: 36931259]
Throughput
- High Throughput
Additional Notes
- BioID
- Interaction confidence score is 1 minus the Bayesian False Discovery Rate (BFDR) calculated from SAINT analysis. Interaction cutoff is BFDR <= 0.01 (confidence score >= 0.99)
- Vehicle control condition
Curated By
- BioGRID