BAIT
YWHAH
YWHA1, LL22NC03-44A4.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
GO Process (15)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- apoptotic process [TAS]
- glucocorticoid catabolic process [IDA]
- glucocorticoid receptor signaling pathway [IDA]
- intracellular protein transport [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane depolarization during action potential [IDA]
- membrane organization [TAS]
- negative regulation of dendrite morphogenesis [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of neuron differentiation [ISS]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of sodium ion transport [IDA]
- regulation of synaptic plasticity [ISS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SETX
ALS4, AOA2, SCAR1, bA479K20.2, RP11-203M2.2
senataxin
GO Process (19)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- DNA duplex unwinding [TAS]
- MAPK cascade [IDA]
- RNA processing [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to oxidative stress [IDA]
- cellular response to retinoic acid [IDA]
- double-strand break repair [IDA]
- fibroblast growth factor receptor signaling pathway [IDA]
- mRNA splice site selection [IMP]
- negative regulation of apoptotic process [IDA]
- positive regulation of DNA-templated transcription, initiation [IMP]
- positive regulation of DNA-templated transcription, termination [IMP]
- positive regulation of RNA splicing [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein kinase B signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A central chaperone-like role for 14-3-3 proteins in human cells.
14-3-3 proteins are highly conserved regulatory proteins that interact with hundreds of structurally diverse clients and act as central hubs of signaling networks. However, how 14-3-3 paralogs differ in specificity and how they regulate client protein function are not known for most clients. Here, we map the interactomes of all human 14-3-3 paralogs and systematically characterize the effect of disrupting ... [more]
Mol Cell Mar. 16, 2023; 83(6);974-993.e15 [Pubmed: 36931259]
Throughput
- High Throughput
Additional Notes
- BioID
- Interaction confidence score is 1 minus the Bayesian False Discovery Rate (BFDR) calculated from SAINT analysis. Interaction cutoff is BFDR <= 0.01 (confidence score >= 0.99)
- okadaic acid (serine/threonine phosphatases inhibition) condition
Curated By
- BioGRID