HSPB1
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular component movement [TAS]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- gene expression [TAS]
- intracellular signal transduction [IMP]
- mRNA metabolic process [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISS]
- negative regulation of protein kinase activity [ISS]
- platelet aggregation [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood vessel endothelial cell migration [IMP]
- positive regulation of endothelial cell chemotaxis [IMP]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IMP]
- positive regulation of interleukin-1 beta production [ISS]
- positive regulation of tumor necrosis factor biosynthetic process [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- regulation of translational initiation [TAS]
- response to unfolded protein [NAS]
- response to virus [IEP]
- retina homeostasis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MSH2
Gene Ontology Biological Process
- ATP catabolic process [IBA, IDA]
- B cell differentiation [ISS]
- B cell mediated immunity [ISS]
- DNA repair [IDA]
- double-strand break repair [IBA]
- intra-S DNA damage checkpoint [IBA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA]
- isotype switching [IBA, ISS]
- maintenance of DNA repeat elements [IMP]
- male gonad development [ISS]
- meiotic gene conversion [IBA]
- meiotic mismatch repair [IBA]
- mismatch repair [IDA, IGI]
- negative regulation of DNA recombination [IDA, ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of reciprocal meiotic recombination [IBA]
- positive regulation of helicase activity [IDA]
- postreplication repair [IDA]
- response to UV-B [IBA, ISS]
- response to X-ray [IBA, ISS]
- somatic hypermutation of immunoglobulin genes [IBA]
- somatic recombination of immunoglobulin gene segments [ISS]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA, IMP]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- single-stranded DNA binding [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA, IMP]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- single-stranded DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Effects of temozolomide (TMZ) on the expression and interaction of heat shock proteins (HSPs) and DNA repair proteins in human malignant glioma cells.
We previously reported the association of HSPA1A and HSPB1 with high-grade astrocytomas, suggesting that these proteins might be involved in disease outcome and response to treatment. With the aim to better understand the resistance/susceptibility processes associated to temozolomide (TMZ) treatment, the current study was performed in three human malignant glioma cell lines by focusing on several levels: (a) apoptotic index ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MSH2 HSPB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID