CUL5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APOBEC3G
Gene Ontology Biological Process
- DNA cytosine deamination [IDA]
- base conversion or substitution editing [TAS]
- cytidine deamination [IDA]
- defense response to virus [IDA]
- innate immune response [IDA]
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [IDA]
- negative regulation of transposition [IDA]
- negative regulation of viral genome replication [IDA]
- negative regulation of viral process [IDA]
- positive regulation of defense response to virus by host [IDA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
An emerging mechanism of ubiquitylation involves partnering of two distinct E3 ligases. In the best-characterized E3-E3 pathways, ARIH-family RING-between-RING (RBR) E3s ligate ubiquitin to substrates of neddylated cullin-RING E3s. The E3 ARIH2 has been implicated in ubiquitylation of substrates of neddylated CUL5-RBX2-based E3s, including APOBEC3-family substrates of the host E3 hijacked by HIV-1 virion infectivity factor (Vif). However, the structural ... [more]
Throughput
- Low Throughput
Additional Notes
- The reaction contained E1, RNF7 and UBE2L3 [E2], and CUL5 and ARIH2 [E3]
Curated By
- BioGRID