NLRC5
Gene Ontology Biological Process
- defense response to virus [IEP]
- innate immune response [IMP, TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of type I interferon production [TAS]
- negative regulation of type I interferon-mediated signaling pathway [IDA]
- positive regulation of MHC class I biosynthetic process [IDA]
- positive regulation of interferon-gamma-mediated signaling pathway [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of type I interferon-mediated signaling pathway [IDA]
- regulation of kinase activity [IDA]
Gene Ontology Molecular Function
TOLLIP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).
NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that the expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID