FHOD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
RAC2
Gene Ontology Biological Process
- actin filament organization [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- lymphocyte aggregation [IMP]
- platelet activation [TAS]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of neutrophil chemotaxis [IMP]
- regulation of cell-substrate adhesion [IMP]
- regulation of hydrogen peroxide metabolic process [TAS]
- regulation of neutrophil migration [IMP]
- regulation of respiratory burst [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.
Formins induce the nucleation and polymerization of unbranched actin filaments. They share three homology domains required for profilin binding, actin polymerization, and regulation. Diaphanous-related formins (DRFs) are activated by GTPases of the Rho/Rac family, whose interaction with the N-terminal formin domain is thought to displace a C-terminal Diaphanous-autoregulatory domain (DAD). We have determined the structure of the N-terminal domains of ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of RAC2 not clear
Curated By
- BioGRID