BAIT
GSK3A
glycogen synthase kinase 3 alpha
GO Process (33)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cardiac left ventricle morphogenesis [ISS]
- cellular protein metabolic process [TAS]
- cellular response to insulin stimulus [IMP]
- cellular response to interleukin-3 [ISS]
- endoplasmic reticulum unfolded protein response [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [ISS]
- negative regulation of TOR signaling [ISS]
- negative regulation of UDP-glucose catabolic process [IC]
- negative regulation of canonical Wnt signaling pathway [TAS]
- negative regulation of cell growth involved in cardiac muscle cell development [ISS]
- negative regulation of glucose import [IMP]
- negative regulation of glycogen (starch) synthase activity [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of transferase activity [IMP]
- negative regulation of type B pancreatic cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of adrenergic receptor signaling pathway [ISS]
- positive regulation of cAMP biosynthetic process [ISS]
- positive regulation of glycogen (starch) synthase activity [ISS]
- positive regulation of heart contraction [ISS]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISS]
- positive regulation of protein catabolic process [NAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA]
- regulation of systemic arterial blood pressure [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APC
BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
adenomatous polyposis coli
GO Process (21)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- apoptotic process [TAS]
- canonical Wnt signaling pathway [IC, NAS]
- cell adhesion [NAS]
- cell cycle arrest [IDA]
- cell migration [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- mitotic cytokinesis [IMP]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of microtubule depolymerization [IDA, IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of protein catabolic process [IC, IGI]
- positive regulation of pseudopodium assembly [IMP]
- protein complex assembly [IDA]
- regulation of attachment of spindle microtubules to kinetochore [IMP, NAS]
- regulation of microtubule-based process [IMP]
- tight junction assembly [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Interactomes of Glycogen Synthase Kinase-3 Isoforms.
Functional differentiation of the two isoforms of the protein-serine/threonine kinase, glycogen synthase kinase-3 (GSK-3), is an unsettled area of research. The isoforms are highly similar in structure and are largely redundant, though there is also evidence for specific roles. Identification of isoform-specific protein interactors may elucidate the differences in function and provide insight into isoform-selective regulation. We therefore sought to ... [more]
J Proteome Res Feb. 13, 2023; (); [Pubmed: 36779422]
Throughput
- High Throughput
Additional Notes
- BioID
- HEK293 cells
- HeLa cells
- SAINT cutoff corresponding to a protein-level Bayesian false discovery rate (BFDR) <= 1%
- SAINT cutoff corresponding to a protein-level Bayesian false discovery rate (BFDR) <= 1%
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GSK3A APC | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3537665 |
Curated By
- BioGRID