BAIT
GSK3A
glycogen synthase kinase 3 alpha
GO Process (33)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cardiac left ventricle morphogenesis [ISS]
- cellular protein metabolic process [TAS]
- cellular response to insulin stimulus [IMP]
- cellular response to interleukin-3 [ISS]
- endoplasmic reticulum unfolded protein response [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [ISS]
- negative regulation of TOR signaling [ISS]
- negative regulation of UDP-glucose catabolic process [IC]
- negative regulation of canonical Wnt signaling pathway [TAS]
- negative regulation of cell growth involved in cardiac muscle cell development [ISS]
- negative regulation of glucose import [IMP]
- negative regulation of glycogen (starch) synthase activity [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of transferase activity [IMP]
- negative regulation of type B pancreatic cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of adrenergic receptor signaling pathway [ISS]
- positive regulation of cAMP biosynthetic process [ISS]
- positive regulation of glycogen (starch) synthase activity [ISS]
- positive regulation of heart contraction [ISS]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISS]
- positive regulation of protein catabolic process [NAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA]
- regulation of systemic arterial blood pressure [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PICALM
CALM, CLTH, LAP
phosphatidylinositol binding clathrin assembly protein
GO Process (22)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- cargo loading into vesicle [IMP]
- cell proliferation [IMP]
- clathrin coat assembly [IMP]
- clathrin-mediated endocytosis [IMP]
- endosomal transport [IMP]
- iron ion homeostasis [IMP]
- iron ion import into cell [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [ISS]
- negative regulation of receptor-mediated endocytosis [IDA]
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISS]
- positive regulation of beta-amyloid formation [IMP]
- positive regulation of neuron death [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- protein complex assembly [TAS]
- receptor internalization [IMP]
- receptor-mediated endocytosis [IDA, ISS]
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [IMP]
- regulation of endocytosis [IMP]
- regulation of protein localization [IDA]
- synaptic vesicle maturation [ISS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- AP-2 adaptor complex [IDA]
- clathrin coat of coated pit [IDA]
- coated pit [IDA, ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [IDA]
- neurofibrillary tangle [IMP]
- neuronal cell body [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISS]
- postsynaptic membrane [ISS]
- presynaptic membrane [ISS]
- vesicle [ISS]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Interactomes of Glycogen Synthase Kinase-3 Isoforms.
Functional differentiation of the two isoforms of the protein-serine/threonine kinase, glycogen synthase kinase-3 (GSK-3), is an unsettled area of research. The isoforms are highly similar in structure and are largely redundant, though there is also evidence for specific roles. Identification of isoform-specific protein interactors may elucidate the differences in function and provide insight into isoform-selective regulation. We therefore sought to ... [more]
J Proteome Res Feb. 13, 2023; (); [Pubmed: 36779422]
Throughput
- High Throughput
Additional Notes
- BioID
- HeLa cells
- SAINT cutoff corresponding to a protein-level Bayesian false discovery rate (BFDR) > 5%
Curated By
- BioGRID