BAIT
FOXO1
FKH1, FKHR, FOXO1A
forkhead box O1
GO Process (30)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to DNA damage stimulus [ISS]
- cellular response to cold [ISS]
- cellular response to hyperoxia [IDA]
- cellular response to insulin stimulus [ISS]
- cellular response to nitric oxide [ISS]
- cellular response to oxidative stress [ISS]
- cellular response to starvation [IDA, ISS]
- endocrine pancreas development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fat cell differentiation [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of stress-activated MAPK cascade [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of apoptotic process [IMP]
- positive regulation of autophagy [IMP]
- positive regulation of protein catabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein acetylation [ISS]
- regulation of energy homeostasis [ISS]
- temperature homeostasis [ISS]
- transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function
Homo sapiens
PREY
S100A9
60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14
S100 calcium binding protein A9
GO Process (18)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- autophagy [IDA]
- cell-cell signaling [TAS]
- chemokine production [TAS]
- cytokine production [TAS]
- defense response to bacterium [TAS]
- defense response to fungus [TAS]
- inflammatory response [TAS]
- leukocyte migration involved in inflammatory response [IDA]
- neutrophil aggregation [IDA]
- neutrophil chemotaxis [IDA]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of cell growth [TAS]
- positive regulation of inflammatory response [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IDA]
- regulation of cytoskeleton organization [TAS]
- sequestering of zinc ion [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology.
Protein?protein interactions (PPIs) are the foundation of the life activities of cells. TurboID is a biotin ligase with higher catalytic efficiency than BioID or APEX that reduces the required labeling time from 18 h to 10 min. Since many proteins participate in binding and catalytic events that are very short-lived, it is theoretically possible to find relatively novel binding proteins using the ... [more]
BMC Genomics Mar. 24, 2023; 24(1);146 [Pubmed: 36964488]
Throughput
- High Throughput
Additional Notes
- FOXO1 overexpression group
- LPS treatment group
- TurboID
Curated By
- BioGRID