BAIT
SLX4
BTBD12, FANCP, MUS312
SLX4 structure-specific endonuclease subunit
GO Process (7)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA double-strand break processing involved in repair via single-strand annealing [IMP]
- DNA repair [IMP]
- double-strand break repair via homologous recombination [IMP]
- nucleotide-excision repair [IMP]
- positive regulation of catalytic activity [IDA]
- response to intra-S DNA damage checkpoint signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AP3M1
RP11-178G16.4
adaptor-related protein complex 3, mu 1 subunit
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.
The DNA repair scaffold SLX4 has pivotal roles in cellular processes that maintain genome stability, most notably homologous recombination. Germline mutations in SLX4 are associated with Fanconi anemia, a disease characterized by chromosome instability and cancer susceptibility. The role of mammalian SLX4 in homologous recombination depends critically on binding and activating structure-selective endonucleases, namely SLX1, MUS81-EME1, and XPF-ERCC1. Increasing evidence ... [more]
J Proteome Res Apr. 18, 2023; (); [Pubmed: 37071664]
Throughput
- High Throughput
Curated By
- BioGRID