BAIT
ARNT
HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2
aryl hydrocarbon receptor nuclear translocator
GO Process (13)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- mRNA transcription from RNA polymerase II promoter [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- response to hypoxia [IDA]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
CLOCK
KAT13D, bHLHe8
clock circadian regulator
GO Process (20)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- cellular response to ionizing radiation [IDA]
- chromatin organization [TAS]
- circadian regulation of gene expression [IDA, IMP, ISS]
- circadian rhythm [TAS]
- histone acetylation [IMP]
- negative regulation of glucocorticoid receptor signaling pathway [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- photoperiodism [TAS]
- positive regulation of NF-kappaB transcription factor activity [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- regulation of hair cycle [IMP]
- regulation of insulin secretion [ISS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription, DNA-templated [ISS]
- regulation of type B pancreatic cell development [ISS]
- response to redox state [IDA]
- spermatogenesis [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- histone acetyltransferase activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS]
- DNA binding [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- histone acetyltransferase activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors.
We report that MOP3 is a general dimerization partner for a subset of the basic-helix-loop-helix (bHLH)-PER-ARNT-SIM (PAS) superfamily of transcriptional regulators. We demonstrated that MOP3 interacts with MOP4, CLOCK, hypoxia-inducible factor 1alpha (HIF1alpha), and HIF2alpha. A DNA selection protocol revealed that the MOP3-MOP4 heterodimer bound a CACGTGA-containing DNA element. Transient transfection experiments demonstrated that the MOP3-MOP4 and MOP3-CLOCK complexes bound ... [more]
Proc. Natl. Acad. Sci. U.S.A. May. 12, 1998; 95(10);5474-9 [Pubmed: 9576906]
Throughput
- Low Throughput
Curated By
- BioGRID