BAIT
CBS
HIP4
cystathionine-beta-synthase
GO Process (10)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- L-cysteine catabolic process [IDA]
- L-serine catabolic process [IDA]
- L-serine metabolic process [IDA]
- cellular nitrogen compound metabolic process [TAS]
- homocysteine catabolic process [IDA]
- homocysteine metabolic process [IDA]
- hydrogen sulfide biosynthetic process [IDA, ISS]
- small molecule metabolic process [TAS]
- sulfur amino acid metabolic process [TAS]
- transsulfuration [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
HSP26
chaperone protein HSP26, L000000817, YBR072W
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic foci; oligomer activation requires heat-induced conformational change; also has mRNA binding activity
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70.
Missense mutant proteins, such as those produced in individuals with genetic diseases, are often misfolded and subject to processing by intracellular quality control systems. Previously, we have shown using a yeast system that enzymatic function could be restored to I278T cystathionine beta-synthase (CBS), a cause of homocystinuria, by treatments that affect the intracellular chaperone environment. Here, we extend these studies ... [more]
PLoS Genet. Jan. 01, 2010; 6(1);e1000807 [Pubmed: 20066033]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Curated By
- BioGRID