PLXNB1
Gene Ontology Biological Process
- axon guidance [TAS]
- cell migration [NAS]
- intracellular signal transduction [NAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of osteoblast proliferation [ISS]
- neuron projection morphogenesis [ISS]
- ossification involved in bone maturation [ISS]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- regulation of cell shape [IDA]
- regulation of cytoskeleton organization [IDA]
- semaphorin-plexin signaling pathway [IDA]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLXNB1
Gene Ontology Biological Process
- axon guidance [TAS]
- cell migration [NAS]
- intracellular signal transduction [NAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of osteoblast proliferation [ISS]
- neuron projection morphogenesis [ISS]
- ossification involved in bone maturation [ISS]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- regulation of cell shape [IDA]
- regulation of cytoskeleton organization [IDA]
- semaphorin-plexin signaling pathway [IDA]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The activity of the plexin-A1 receptor is regulated by Rac.
Plexins constitute a large family of transmembrane proteins that act as receptors for the semaphorin family of ligands. They are best known for their role in growth cone guidance, although they also are widely expressed outside the nervous system. Plexins are thought to control axon guidance by modifying the growth cone cytoskeleton, and Rho GTPases have been strongly implicated in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PLXNB1 PLXNB1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID