LRP1
Gene Ontology Biological Process
- U4 snRNA 3'-end processing [IMP]
- U5 snRNA 3'-end processing [IMP]
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- nuclear mRNA surveillance [IMP]
- nuclear polyadenylation-dependent CUT catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent rRNA catabolic process [IGI, IMP]
- nuclear retention of pre-mRNA at the site of transcription [IGI]
- polyadenylation-dependent snoRNA 3'-end processing [IMP]
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
- regulation of exoribonuclease activity [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SUB1
Gene Ontology Biological Process
- RNA polymerase III transcriptional preinitiation complex assembly [IDA]
- double-strand break repair via nonhomologous end joining [IMP]
- hyperosmotic response [IGI]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IPI]
- positive regulation of transcription from RNA polymerase III promoter [IDA, IGI, IMP]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription from RNA polymerase II promoter in response to stress [IDA, IGI, IMP]
- termination of RNA polymerase II transcription [IGI]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.
A genome-wide screen for synthetic lethal (SL) interactions with loss of the nuclear exosome cofactors Rrp47/Lrp1 or Air1 identified 3'-->5' exonucleases, the THO complex required for mRNP assembly, and Ynr024w (Mpp6). SL interactions with mpp6Delta were confirmed for rrp47Delta and nuclear exosome component Rrp6. The results of bioinformatic analyses revealed homology between Mpp6 and a human exosome cofactor, underlining the ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUB1 LRP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1241 | BioGRID | 2161322 |
Curated By
- BioGRID