SETX
Gene Ontology Biological Process
- DNA duplex unwinding [TAS]
- MAPK cascade [IDA]
- RNA processing [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to oxidative stress [IDA]
- cellular response to retinoic acid [IDA]
- double-strand break repair [IDA]
- fibroblast growth factor receptor signaling pathway [IDA]
- mRNA splice site selection [IMP]
- negative regulation of apoptotic process [IDA]
- positive regulation of DNA-templated transcription, initiation [IMP]
- positive regulation of DNA-templated transcription, termination [IMP]
- positive regulation of RNA splicing [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein kinase B signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SUMO1
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular protein metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of DNA binding [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- palate development [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein complex assembly [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of protein localization [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide.
Senataxin is a large 303 kDa protein linked to neuron survival, as recessive mutations cause Ataxia with Oculomotor Apraxia type 2 (AOA2), and dominant mutations cause amyotrophic lateral sclerosis type 4 (ALS4). Senataxin contains an amino-terminal protein-interaction domain and a carboxy-terminal DNA/RNA helicase domain. In this study, we focused upon the common ALS4 mutation, L389S, by performing yeast two-hybrid screens ... [more]
Throughput
- High Throughput|Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUMO1 SETX | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 904683 |
Curated By
- BioGRID