BRSK1
Gene Ontology Biological Process
- G2 DNA damage checkpoint [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- axonogenesis [IMP]
- cellular response to DNA damage stimulus [ISO]
- centrosome duplication [IMP]
- establishment of cell polarity [IGI, IMP]
- neuron differentiation [IGI]
- neuron projection morphogenesis [IGI]
- neurotransmitter secretion [ISO]
- peptidyl-serine phosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to UV [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDC25C
Gene Ontology Biological Process
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Structure and inhibition analysis of the mouse SAD-B C-terminal fragment.
The SAD (synapses of amphids defective) kinases, including SAD-A and SAD-B, play important roles in the regulation of neuronal development, cell cycle, and energy metabolism. Our recent study of mouse SAD-A identified a unique autoinhibitory sequence (AIS), which binds at the junction of the kinase domain (KD) and the ubiquitin-associated (UBA) domain and exerts autoregulation in cooperation with UBA. Here, ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of hit is unclear
Curated By
- BioGRID