BAIT
ATP1B4
1110020B02Rik, RP23-476D16.3
ATPase, (Na+)/K+ transporting, beta 4 polypeptide
GO Process (1)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HMOX2
HO-2, HO2
heme oxygenase (decycling) 2
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals.
ATP1B4 genes represent a rare instance of orthologous vertebrate gene co-option that radically changed properties of the encoded BetaM proteins, which function as Na,K-ATPase subunits in lower vertebrates and birds. Eutherian BetaM has lost its ancestral function and became a muscle-specific resident of the inner nuclear membrane. Our earlier work implicated BetaM in regulation of gene expression through direct interaction ... [more]
Sci Rep Mar. 04, 2016; 6();22395 [Pubmed: 26939788]
Throughput
- High Throughput
Curated By
- BioGRID