BAIT
C16ORF72
PRO0149
chromosome 16 open reading frame 72
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
GLS
AAD20, GAC, GAM, GLS1, KGA
glutaminase
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cellular amino acid biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- glutamate biosynthetic process [IDA, TAS]
- glutamate secretion [TAS]
- glutamine catabolic process [IDA, NAS]
- neurotransmitter secretion [TAS]
- protein homotetramerization [IDA]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.
Telomere erosion in cells with insufficient levels of the telomerase reverse transcriptase (TERT), contributes to age-associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome-wide CRISPR screen to identify gene deletions that sensitized p53-positive human cells to telomerase inhibition. We uncovered a previously unannotated gene, C16ORF72, which we term Telomere Attrition and ... [more]
Aging Cell Apr. 01, 2021; 20(4);e13331 [Pubmed: 33660365]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID