BAIT
ADAM10
1700031C13Rik, MADM, kuz, kuzbanian, RP24-68C7.1
a disintegrin and metallopeptidase domain 10
GO Process (16)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- Notch receptor processing [NAS]
- Notch signaling pathway [IMP]
- PMA-inducible membrane protein ectodomain proteolysis [ISO]
- constitutive protein ectodomain proteolysis [ISO]
- in utero embryonic development [IMP]
- membrane protein ectodomain proteolysis [ISO]
- monocyte activation [ISO]
- negative regulation of cell adhesion [ISO]
- nucleocytoplasmic transport [NAS]
- positive regulation of T cell chemotaxis [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- protein phosphorylation [IDA]
- proteolysis [IMP]
- response to tumor necrosis factor [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi-associated vesicle [ISO]
- cell [NAS]
- cell surface [ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular [NAS]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- nucleus [IDA]
- perinuclear endoplasmic reticulum [ISO]
- postsynaptic density [IDA]
- tetraspanin-enriched microdomain [ISO]
- trans-Golgi network [ISO]
Mus musculus
PREY
ACTN2
1110008F24Rik
actinin alpha 2
GO Process (12)
GO Function (14)
GO Component (7)
Gene Ontology Biological Process
- focal adhesion assembly [ISO]
- microspike assembly [ISO]
- muscle contraction [IDA]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of potassium ion transport [ISO]
- negative regulation of protein localization to cell surface [ISO]
- positive regulation of potassium ion transmembrane transporter activity [ISO]
- positive regulation of potassium ion transport [ISO]
- positive regulation of receptor activity [IDA]
- protein homotetramerization [ISO]
- regulation of membrane potential [ISO]
- regulation of nucleic acid-templated transcription [IDA]
Gene Ontology Molecular Function- FATZ binding [ISO]
- LIM domain binding [IPI]
- actin filament binding [IDA, TAS]
- cytoskeletal protein binding [IDA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein dimerization activity [ISO]
- protein homodimerization activity [TAS]
- thyroid hormone receptor coactivator activity [IDA]
- titin Z domain binding [ISO]
- titin binding [ISO]
- FATZ binding [ISO]
- LIM domain binding [IPI]
- actin filament binding [IDA, TAS]
- cytoskeletal protein binding [IDA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein dimerization activity [ISO]
- protein homodimerization activity [TAS]
- thyroid hormone receptor coactivator activity [IDA]
- titin Z domain binding [ISO]
- titin binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Synaptic dysfunction and cognitive decline in Huntington's disease (HD) involve hyperactive A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10). To identify the molecular mechanisms through which ADAM10 is associated with synaptic dysfunction in HD, we performed an immunoaffinity purification-mass spectrometry (IP-MS) study of endogenous ADAM10 in the brains of wild-type and HD mice. We found that proteins implicated in synapse ... [more]
Hum Mol Genet Jun. 17, 2021; 30(13);1175-1187 [Pubmed: 33601422]
Throughput
- Low Throughput
Curated By
- BioGRID