BAIT
ADAM10
1700031C13Rik, MADM, kuz, kuzbanian, RP24-68C7.1
a disintegrin and metallopeptidase domain 10
GO Process (16)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- Notch receptor processing [NAS]
- Notch signaling pathway [IMP]
- PMA-inducible membrane protein ectodomain proteolysis [ISO]
- constitutive protein ectodomain proteolysis [ISO]
- in utero embryonic development [IMP]
- membrane protein ectodomain proteolysis [ISO]
- monocyte activation [ISO]
- negative regulation of cell adhesion [ISO]
- nucleocytoplasmic transport [NAS]
- positive regulation of T cell chemotaxis [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- protein phosphorylation [IDA]
- proteolysis [IMP]
- response to tumor necrosis factor [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi-associated vesicle [ISO]
- cell [NAS]
- cell surface [ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular [NAS]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- nucleus [IDA]
- perinuclear endoplasmic reticulum [ISO]
- postsynaptic density [IDA]
- tetraspanin-enriched microdomain [ISO]
- trans-Golgi network [ISO]
Mus musculus
PREY
ANK2
AI835472, AW491075, Ank-2
ankyrin 2, brain
GO Process (33)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- SA node cell action potential [IMP]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- T-tubule organization [IMP]
- atrial cardiac muscle cell action potential [IMP]
- atrial cardiac muscle cell to AV node cell communication [IMP]
- cardiac muscle contraction [IMP]
- cellular calcium ion homeostasis [IMP]
- cellular protein localization [IMP]
- positive regulation of calcium ion transmembrane transporter activity [IMP]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cation channel activity [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of potassium ion transmembrane transporter activity [IMP]
- positive regulation of potassium ion transport [IMP]
- protein localization [IMP]
- protein localization to M-band [IMP]
- protein localization to T-tubule [IMP]
- protein localization to cell surface [IMP]
- protein localization to endoplasmic reticulum [IMP]
- protein localization to plasma membrane [IMP]
- protein stabilization [IMP]
- protein targeting to plasma membrane [IGI, IMP]
- regulation of calcium ion transmembrane transporter activity [IMP]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cardiac muscle cell membrane potential [IGI, IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, IMP]
- regulation of cation channel activity [IMP]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of protein stability [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- A band [IDA]
- M band [IDA, IMP]
- T-tubule [IDA]
- Z disc [IDA]
- cell [IGI]
- costamere [IDA]
- cytoplasm [IDA]
- integral component of plasma membrane [IDA]
- intercalated disc [IDA]
- intracellular [IGI, IMP]
- neuronal postsynaptic density [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, IMP]
- sarcolemma [IDA, IMP]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Synaptic dysfunction and cognitive decline in Huntington's disease (HD) involve hyperactive A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10). To identify the molecular mechanisms through which ADAM10 is associated with synaptic dysfunction in HD, we performed an immunoaffinity purification-mass spectrometry (IP-MS) study of endogenous ADAM10 in the brains of wild-type and HD mice. We found that proteins implicated in synapse ... [more]
Hum Mol Genet Jun. 17, 2021; 30(13);1175-1187 [Pubmed: 33601422]
Throughput
- Low Throughput
Curated By
- BioGRID