BAIT
ADAM10
1700031C13Rik, MADM, kuz, kuzbanian, RP24-68C7.1
a disintegrin and metallopeptidase domain 10
GO Process (16)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- Notch receptor processing [NAS]
- Notch signaling pathway [IMP]
- PMA-inducible membrane protein ectodomain proteolysis [ISO]
- constitutive protein ectodomain proteolysis [ISO]
- in utero embryonic development [IMP]
- membrane protein ectodomain proteolysis [ISO]
- monocyte activation [ISO]
- negative regulation of cell adhesion [ISO]
- nucleocytoplasmic transport [NAS]
- positive regulation of T cell chemotaxis [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- protein phosphorylation [IDA]
- proteolysis [IMP]
- response to tumor necrosis factor [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi-associated vesicle [ISO]
- cell [NAS]
- cell surface [ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular [NAS]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- nucleus [IDA]
- perinuclear endoplasmic reticulum [ISO]
- postsynaptic density [IDA]
- tetraspanin-enriched microdomain [ISO]
- trans-Golgi network [ISO]
Mus musculus
PREY
MAPK1
9030612K14Rik, AA407128, AU018647, C78273, ERK, Erk2, MAPK2, PRKM2, Prkm1, p41mapk, p42mapk
mitogen-activated protein kinase 1
GO Process (35)
GO Function (12)
GO Component (18)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IDA, IMP, ISO]
- MAPK import into nucleus [ISO]
- T cell receptor signaling pathway [IDA]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to organic substance [ISO]
- cytosine metabolic process [IDA]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [IMP]
- lipopolysaccharide-mediated signaling pathway [IDA]
- mammary gland epithelial cell proliferation [IDA]
- negative regulation of cell differentiation [IGI]
- organ morphogenesis [IDA]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of translation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [NAS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO]
- response to estrogen [ISO]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to toxic substance [ISO]
- sensory perception of pain [ISO]
- signal transduction [ISO]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [ISO]
- caveola [TAS]
- cytoplasm [IDA, ISO]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [ISO]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [IDA, TAS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, TAS]
- perikaryon [ISO]
- protein complex [ISO]
- pseudopodium [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Synaptic dysfunction and cognitive decline in Huntington's disease (HD) involve hyperactive A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10). To identify the molecular mechanisms through which ADAM10 is associated with synaptic dysfunction in HD, we performed an immunoaffinity purification-mass spectrometry (IP-MS) study of endogenous ADAM10 in the brains of wild-type and HD mice. We found that proteins implicated in synapse ... [more]
Hum Mol Genet Jun. 17, 2021; 30(13);1175-1187 [Pubmed: 33601422]
Throughput
- Low Throughput
Curated By
- BioGRID