BAIT
ADAM10
1700031C13Rik, MADM, kuz, kuzbanian, RP24-68C7.1
a disintegrin and metallopeptidase domain 10
GO Process (16)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- Notch receptor processing [NAS]
- Notch signaling pathway [IMP]
- PMA-inducible membrane protein ectodomain proteolysis [ISO]
- constitutive protein ectodomain proteolysis [ISO]
- in utero embryonic development [IMP]
- membrane protein ectodomain proteolysis [ISO]
- monocyte activation [ISO]
- negative regulation of cell adhesion [ISO]
- nucleocytoplasmic transport [NAS]
- positive regulation of T cell chemotaxis [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- protein phosphorylation [IDA]
- proteolysis [IMP]
- response to tumor necrosis factor [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi-associated vesicle [ISO]
- cell [NAS]
- cell surface [ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular [NAS]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- nucleus [IDA]
- perinuclear endoplasmic reticulum [ISO]
- postsynaptic density [IDA]
- tetraspanin-enriched microdomain [ISO]
- trans-Golgi network [ISO]
Mus musculus
PREY
WNK1
6430573H23Rik, EG406236, Hsn2, Prkwnk1, mKIAA0344
WNK lysine deficient protein kinase 1
GO Process (10)
GO Function (10)
GO Component (1)
Gene Ontology Biological Process
- intracellular signal transduction [ISO]
- ion transport [IDA]
- negative regulation of kinase activity [ISO]
- negative regulation of pancreatic juice secretion [IMP]
- negative regulation of phosphatase activity [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of systemic arterial blood pressure [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of cellular process [IDA]
Gene Ontology Molecular Function- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Synaptic dysfunction and cognitive decline in Huntington's disease (HD) involve hyperactive A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10). To identify the molecular mechanisms through which ADAM10 is associated with synaptic dysfunction in HD, we performed an immunoaffinity purification-mass spectrometry (IP-MS) study of endogenous ADAM10 in the brains of wild-type and HD mice. We found that proteins implicated in synapse ... [more]
Hum Mol Genet Jun. 17, 2021; 30(13);1175-1187 [Pubmed: 33601422]
Throughput
- Low Throughput
Curated By
- BioGRID