BAIT

C16ORF72

PRO0149
chromosome 16 open reading frame 72
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

ATRX

ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX, RP5-875J14.1
alpha thalassemia/mental retardation syndrome X-linked
Glioblastoma Project
UPS Project
Homo sapiens

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

Benslimane Y, Sanchez-Osuna M, Coulombe-Huntington J, Bertomeu T, Henry D, Huard C, Bonneil E, Thibault P, Tyers M, Harrington L

Telomere erosion in cells with insufficient levels of the telomerase reverse transcriptase (TERT), contributes to age-associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome-wide CRISPR screen to identify gene deletions that sensitized p53-positive human cells to telomerase inhibition. We uncovered a previously unannotated gene, C16ORF72, which we term Telomere Attrition and ... [more]

Aging Cell Apr. 01, 2021; 20(4);e13331 [Pubmed: 33660365]

Throughput

  • High Throughput

Ontology Terms

  • growth abnormality (HP:0001507) [viability (PATO:0000169)]

Additional Notes

  • CRISPR GI screen
  • Cell Line: NALM-6
  • Experimental Setup: Timecourse
  • GIST: A-phenotypic negative genetic interaction
  • Library: TKOv3
  • Significance Threshold: <-4.1

Curated By

  • BioGRID