An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer.

Ren Y, Feng M, Hao X, Liu X, Li J, Li P, Gao J, Qi Q, Du L, Wang C, Wang Q, Wang Y

Pyroptosis is a type of programmed cell death characterized by the activation of inflammatory caspases and the cleavage of gasdermin proteins. Pyroptosis can suppress tumor development and induce antitumor immunity, and activating pyroptosis is a potential treatment strategy for cancer. To uncover approaches to harness the anticancer effects of pyroptosis, we aimed to identify regulators of pyroptosis in cancer. A ... [more]

Cancer Res Apr. 04, 2023; 83(7);1074-1093 [Pubmed: 36607699]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

USP48

Gene Ontology Biological Process

Gene Ontology Molecular Function

cysteine-type endopeptidase activity [IBA]ubiquitin thiolesterase activity [IBA]ubiquitin-specific protease activity [IBA]

Gene Ontology Cellular Component

CA1