BAIT

MAPT

DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU

microtubule-associated protein tau

Synthetic Protein Interaction Project

GO Process (8)

GO Function (7)

GO Component (8)

Gene Ontology Biological Process

apoptotic process [TAS]

cellular component disassembly involved in execution phase of apoptosis [TAS]

generation of neurons [NAS]

microtubule cytoskeleton organization [IDA]

positive regulation of axon extension [IDA]

positive regulation of microtubule polymerization [IDA]

regulation of autophagy [IGI]

regulation of microtubule polymerization [NAS]

Gene Ontology Molecular Function

SH3 domain binding [IPI]
apolipoprotein binding [IPI]
enzyme binding [IPI]
lipoprotein particle binding [IPI]
microtubule binding [IDA]
protein binding [IPI]
structural constituent of cytoskeleton [TAS]

Gene Ontology Cellular Component

cytoplasmic ribonucleoprotein granule [IDA]

growth cone [IDA]

microtubule associated complex [TAS]

nuclear periphery [IDA]

plasma membrane [IDA]

tubulin complex [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

UBE2I

C358B7.1, P18, UBC9, LA16c-358B7.1

ubiquitin-conjugating enzyme E2I

GO Process (8)

GO Function (9)

GO Component (6)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

cellular protein modification process [TAS]

negative regulation of transcription from RNA polymerase II promoter [IMP]

negative regulation of transcription, DNA-templated [IDA]

post-translational protein modification [TAS]

protein sumoylation [IDA, TAS]

protein ubiquitination [IBA]

ubiquitin-dependent protein catabolic process [TAS]

Gene Ontology Molecular Function

RING-like zinc finger domain binding [IPI]
SUMO transferase activity [IDA]
enzyme binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
transcription factor binding [IPI]
ubiquitin protein ligase activity [IBA]
ubiquitin protein ligase binding [IBA]
ubiquitin-protein transferase activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleoplasm [TAS]

synaptonemal complex [TAS]

transferase complex [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Fibril treatment changes protein interactions of tau and ?-synuclein in human neurons.

Griffin TA, Schnier PD, Cleveland EM, Newberry RW, Becker J, Carlson GA

In several neurodegenerative disorders, the neuronal proteins tau and ?-synuclein adopt aggregation-prone conformations capable of replicating within and between cells. To better understand how these conformational changes drive neuropathology, we compared the interactomes of tau and ?-synuclein in the presence or the absence of recombinant fibril seeds. Human embryonic stem cells with an inducible neurogenin-2 transgene were differentiated into glutamatergic ... [more]

J Biol Chem Mar. 01, 2023; 299(3);102888 [Pubmed: 36634849]

Throughput

Low Throughput

Additional Notes

0N4R Tau (WT) 3wks post-seeding
BioID2

Curated By

BioGRID