BAIT
MAPT
DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
microtubule-associated protein tau
GO Process (8)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PNKP
EIEE10, MCSZ, PNK
polynucleotide kinase 3'-phosphatase
GO Process (10)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA, NAS]
- DNA repair [IGI]
- DNA-dependent DNA replication [NAS]
- dephosphorylation [IDA]
- nucleic acid phosphodiester bond hydrolysis [NAS]
- nucleotide phosphorylation [IDA]
- nucleotide-excision repair, DNA damage removal [NAS]
- polynucleotide 3' dephosphorylation [IDA]
- response to oxidative stress [IDA]
- response to radiation [NAS, TAS]
Gene Ontology Molecular Function- ATP binding [NAS]
- ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [IDA]
- damaged DNA binding [NAS]
- double-stranded DNA binding [TAS]
- endonuclease activity [NAS]
- nucleotide kinase activity [IDA]
- polynucleotide 3'-phosphatase activity [IDA]
- protein binding [IPI]
- purine nucleotide binding [NAS]
- ATP binding [NAS]
- ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [IDA]
- damaged DNA binding [NAS]
- double-stranded DNA binding [TAS]
- endonuclease activity [NAS]
- nucleotide kinase activity [IDA]
- polynucleotide 3'-phosphatase activity [IDA]
- protein binding [IPI]
- purine nucleotide binding [NAS]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Fibril treatment changes protein interactions of tau and ?-synuclein in human neurons.
In several neurodegenerative disorders, the neuronal proteins tau and ?-synuclein adopt aggregation-prone conformations capable of replicating within and between cells. To better understand how these conformational changes drive neuropathology, we compared the interactomes of tau and ?-synuclein in the presence or the absence of recombinant fibril seeds. Human embryonic stem cells with an inducible neurogenin-2 transgene were differentiated into glutamatergic ... [more]
J Biol Chem Mar. 01, 2023; 299(3);102888 [Pubmed: 36634849]
Throughput
- High Throughput
Additional Notes
- 0N4R Tau (P301L) 3wks post-seeding
- 0N4R Tau (WT) 3wks post-seeding
- BioID2
Curated By
- BioGRID