MAPT
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB3A
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- Rab protein signal transduction [IBA]
- constitutive secretory pathway [TAS]
- glutamate secretion [TAS]
- intracellular protein transport [IBA]
- neurotransmitter secretion [TAS]
- positive regulation of exocytosis [TAS]
- positive regulation of regulated secretory pathway [IMP]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of short-term neuronal synaptic plasticity [ISS]
- regulation of synaptic vesicle fusion to presynaptic membrane [ISS]
- synaptic transmission [TAS]
- synaptic vesicle exocytosis [ISS]
- synaptic vesicle recycling [ISS]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- clathrin-sculpted acetylcholine transport vesicle membrane [TAS]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- clathrin-sculpted glutamate transport vesicle membrane [TAS]
- clathrin-sculpted monoamine transport vesicle membrane [TAS]
- endosome [IBA]
- plasma membrane [TAS]
- secretory granule membrane [IBA]
- synaptic vesicle [ISS]
- terminal bouton [ISS]
- vesicle [IDA]
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Fibril treatment changes protein interactions of tau and ?-synuclein in human neurons.
In several neurodegenerative disorders, the neuronal proteins tau and ?-synuclein adopt aggregation-prone conformations capable of replicating within and between cells. To better understand how these conformational changes drive neuropathology, we compared the interactomes of tau and ?-synuclein in the presence or the absence of recombinant fibril seeds. Human embryonic stem cells with an inducible neurogenin-2 transgene were differentiated into glutamatergic ... [more]
Throughput
- High Throughput
Additional Notes
- 0N4R Tau (P301L) 3wks post-seeding
- BioID2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAPT RAB3A | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3662088 |
Curated By
- BioGRID