BAIT
TNIP1
ABIN-1, NAF1, VAN, nip40-1
TNFAIP3 interacting protein 1
GO Process (11)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [ISS]
- defense response [TAS]
- glycoprotein biosynthetic process [IDA]
- leukocyte cell-cell adhesion [IMP]
- modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of viral genome replication [TAS]
- positive regulation of inflammatory response [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NRP1
BDCA4, CD304, NP1, NRP, VEGF165R, RP11-342D11.1
neuropilin 1
GO Process (43)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- angiogenesis [IMP, ISS]
- angiogenesis involved in coronary vascular morphogenesis [ISS]
- artery morphogenesis [ISS]
- axon extension involved in axon guidance [ISS]
- axon guidance [NAS, TAS]
- axonogenesis involved in innervation [ISS]
- cell migration involved in sprouting angiogenesis [ISS]
- cell-cell signaling [TAS]
- cellular response to hepatocyte growth factor stimulus [IMP]
- cellular response to vascular endothelial growth factor stimulus [ISS]
- commissural neuron axon guidance [ISS]
- endothelial cell chemotaxis [IMP]
- endothelial tip cell fate specification [ISS]
- hepatocyte growth factor receptor signaling pathway [IMP]
- nerve development [ISS]
- neural crest cell migration involved in autonomic nervous system development [ISS]
- neuron migration [ISS]
- organ morphogenesis [TAS]
- patterning of blood vessels [ISS]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive chemotaxis [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of cytokine activity [TAS]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of endothelial cell proliferation [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of smooth muscle cell migration [TAS]
- protein localization to early endosome [ISS]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of vesicle-mediated transport [TAS]
- retina vasculature morphogenesis in camera-type eye [ISS]
- retinal ganglion cell axon guidance [ISS]
- semaphorin-plexin signaling pathway [NAS]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISS]
- signal transduction [TAS]
- sprouting angiogenesis [ISS]
- sympathetic ganglion development [ISS]
- sympathetic neuron projection extension [ISS]
- sympathetic neuron projection guidance [ISS]
- vascular endothelial growth factor receptor signaling pathway [IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
Mitophagy is a form of selective autophagy that disposes of superfluous and potentially damage-inducing organelles in a tightly controlled manner. While the machinery involved in mitophagy induction is well known, the regulation of the components is less clear. Here, we demonstrate that TNIP1 knockout in HeLa cells accelerates mitophagy rates and that ectopic TNIP1 negatively regulates the rate of mitophagy. ... [more]
Mol Cell Mar. 16, 2023; 83(6);927-941.e8 [Pubmed: 36898370]
Throughput
- High Throughput
Additional Notes
- Any protein scoring above 1 and having a CRAPome score above 0.7 is considered a high confidence interactor.
- HA-IP dataset
Curated By
- BioGRID