BAIT
SETDB1
ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21, RP11-316M1.1
SET domain, bifurcated 1
GO Process (0)
GO Function (1)
GO Component (5)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LDHB
HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5
lactate dehydrogenase B
GO Process (3)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.
The histone methyltransferase SETDB1 plays a central role in repressive chromatin processes, but the functional requirement for its binding partner ATF7IP has remained enigmatic. Here, we show that ATF7IP is essential for SETDB1 stability: nuclear SETDB1 protein is degraded by the proteasome upon ablation of ATF7IP. As a result, ATF7IP is critical for repression that requires H3K9 trimethylation by SETDB1, including transgene ... [more]
Cell Rep Oct. 11, 2016; 17(3);653-659 [Pubmed: 27732843]
Throughput
- High Throughput
Curated By
- BioGRID