BAIT
ADARB1
ADAR2, DRABA2, DRADA2, RED1
adenosine deaminase, RNA-specific, B1
GO Process (10)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- RNA processing [IDA]
- adenosine to inosine editing [IDA, TAS]
- base conversion or substitution editing [IC]
- gene expression [TAS]
- mRNA modification [TAS]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA]
- positive regulation of viral genome replication [IMP]
- regulation of cell cycle [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
LMNA
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, RP11-54H19.1
lamin A/C
GO Process (14)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [ISS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle organ development [IMP]
- positive regulation of cell aging [IDA]
- protein localization to nucleus [ISS]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.
Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified. We perform BioID followed by mass spectrometry to identify trans regulators of ADAR1 and ADAR2 in HeLa and M17 neuroblastoma cells. We identify known and novel ADAR-interacting proteins. Using ... [more]
Cell Rep May. 19, 2020; 31(7);107656 [Pubmed: 32433965]
Throughput
- High Throughput
Additional Notes
- BioID
- High confidence protein hits had fold changes of LFC > 2 in at least two biological replicates.
- M17 cells
Curated By
- BioGRID