TUB3
Gene Ontology Biological Process
Gene Ontology Cellular Component
PAC10
Gene Ontology Biological Process
Gene Ontology Molecular Function
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Tubulin isotypes optimize distinct spindle positioning mechanisms during yeast mitosis.
Microtubules are dynamic cytoskeleton filaments that are essential for a wide range of cellular processes. They are polymerized from tubulin, a heterodimer of ?- and ?-subunits. Most eukaryotic organisms express multiple isotypes of ?- and ?-tubulin, yet their functional relevance in any organism remains largely obscure. The two ?-tubulin isotypes in budding yeast, Tub1 and Tub3, are proposed to be ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- SGA genetic interaction dataset for the loss of TUB3. All reported hits have P value < 0.05. Negative synthetic genetic integrations have score < -0.08, while positive synthetic integrations have score > 0.08.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PAC10 TUB3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4221 | BioGRID | 2120745 | |
| TUB3 PAC10 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1424 | BioGRID | 2160206 | |
| TUB3 PAC10 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 159050 | |
| PAC10 TUB3 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 162554 | |
| TUB3 PAC10 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 110614 | |
| PAC10 TUB3 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 110615 |
Curated By
- BioGRID