BAIT
OPRD1
OPRD
opioid receptor, delta 1
GO Process (16)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- cellular response to hypoxia [IDA]
- cellular response to toxic substance [IDA]
- immune response [TAS]
- negative regulation of gene expression [IDA]
- negative regulation of protein oligomerization [IDA]
- neuropeptide signaling pathway [IBA]
- opioid receptor signaling pathway [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISS]
- positive regulation of CREB transcription factor activity [IC]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- protein import into nucleus, translocation [IDA]
- regulation of mitochondrial membrane potential [IDA]
- sensory perception of pain [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WWP2
AIP2, WWp2-like
WW domain containing E3 ubiquitin protein ligase 2
GO Process (16)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cellular protein modification process [TAS]
- negative regulation of gene expression [IMP]
- negative regulation of protein transport [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- negative regulation of transcription, DNA-templated [ISS]
- negative regulation of transporter activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein K63-linked ubiquitination [ISS]
- protein autoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of ion transmembrane transport [IDA]
- regulation of membrane potential [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.
Cells operate through protein interaction networks organized in space and time. Here, we describe an approach to resolve both dimensions simultaneously by using proximity labeling mediated by engineered ascorbic acid peroxidase (APEX). APEX has been used to capture entire organelle proteomes with high temporal resolution, but its breadth of labeling is generally thought to preclude the higher spatial resolution necessary ... [more]
Cell Apr. 06, 2017; 169(2);350-360.e12 [Pubmed: 28388416]
Throughput
- High Throughput
Curated By
- BioGRID