BAIT

MAPT

DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU

microtubule-associated protein tau

Synthetic Protein Interaction Project

GO Process (8)

GO Function (7)

GO Component (8)

Gene Ontology Biological Process

apoptotic process [TAS]

cellular component disassembly involved in execution phase of apoptosis [TAS]

generation of neurons [NAS]

microtubule cytoskeleton organization [IDA]

positive regulation of axon extension [IDA]

positive regulation of microtubule polymerization [IDA]

regulation of autophagy [IGI]

regulation of microtubule polymerization [NAS]

Gene Ontology Molecular Function

SH3 domain binding [IPI]
apolipoprotein binding [IPI]
enzyme binding [IPI]
lipoprotein particle binding [IPI]
microtubule binding [IDA]
protein binding [IPI]
structural constituent of cytoskeleton [TAS]

Gene Ontology Cellular Component

cytoplasmic ribonucleoprotein granule [IDA]

growth cone [IDA]

microtubule associated complex [TAS]

nuclear periphery [IDA]

plasma membrane [IDA]

tubulin complex [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

HNRNPC

C1, C2, HNRNP, HNRPC, SNRPC

heterogeneous nuclear ribonucleoprotein C (C1/C2)

GO Process (6)

GO Function (9)

GO Component (9)

Gene Ontology Biological Process

3'-UTR-mediated mRNA stabilization [IMP]

ATP-dependent chromatin remodeling [IDA]

RNA splicing [TAS]

gene expression [TAS]

mRNA splicing, via spliceosome [IC, TAS]

osteoblast differentiation [IDA]

Gene Ontology Molecular Function

RNA binding [NAS]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
identical protein binding [IPI]
mRNA 3'-UTR binding [IDA]
nucleosomal DNA binding [IDA]
poly(A) RNA binding [IDA]
poly(U) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

catalytic step 2 spliceosome [IDA]

extracellular vesicular exosome [IDA]

nuclear chromatin [IDA]

nucleoplasm [IDA, TAS]

protein complex [IDA]

spliceosomal complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

Identification of HnRNPC as a novel Tau exon 10 splicing factor using RNA antisense purification mass spectrometry.

Xing S, Wang J, Wu R, Hefti MM, Crary JF, Lu Y

Alternative splicing in Tau exon 10 generates 3 R- and 4 R-Tau proteoforms, which have equal abundance in healthy adult human brain. Aberrant alternative splicing in Tau exon 10 leads to distortion of the balanced 3 R- and 4 R-Tau expression levels, which is a causal factor to trigger toxic Tau aggregation, neuron dysfunction and patient death in a group of neurodegenerative diseases known ... [more]

RNA Biol Dec. 30, 2021; 19(1);104-116 [Pubmed: 34965173]

Throughput

Low Throughput

Curated By

BioGRID