BAIT

NSP5

ORF1ab, ORF1ab-nsp5, SARS-CoV2 nsp5, SARS-CoV-2 nsp5, Mpro, 3CLpro, 3C-like proteinase, R1AB_SARS2, PRO_0000449623, GU280_gp01_nsp5
3C-like proteinase; Non-structural protein 5
COVID-19 Coronavirus Project
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus 2
PREY

BLVRB

BVRB, FLR, HEL-S-10, SDR43U1
biliverdin reductase B
Homo sapiens

Biochemical Activity (Proteolytic Processing)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

Koudelka T, Boger J, Henkel A, Schoenherr R, Krantz S, Fuchs S, Rodriguez E, Redecke L, Tholey A

The genome of coronaviruses, including SARS-CoV-2, encodes for two proteases, a papain like (PLpro ) protease and the so-called main protease (Mpro ), a chymotrypsin-like cysteine protease, also named 3CLpro or non-structural protein 5 (nsp5). Mpro is activated by autoproteolysis and is the main protease responsible for cutting the viral polyprotein into functional units. Aside from this, it is described ... [more]

Proteomics Jan. 01, 2021; 21(2);e2000246 [Pubmed: 33111431]

Throughput

  • Low Throughput

Curated By

  • BioGRID