An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.

Merle DA, Provenzano F, Jarboui MA, Kilger E, Clark SJ, Deleidi M, Armento A, Ueffing M

Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices. The combination of these factors leads to oxidative stress, inflammation, and metabolic failure in the retinal pigment epithelium (RPE) with subsequent degeneration of photoreceptors in the retina. The alternative complement pathway is tightly linked to AMD. In particular, ... [more]

Antioxidants (Basel) Dec. 03, 2021; 10(12); [Pubmed: 34943047]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

CFH

Gene Ontology Biological Process

Gene Ontology Molecular Function

heparan sulfate proteoglycan binding [IDA]heparin binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

GNB4