BAIT

GLDC

GCE, GCSP, HYGN1, RP11-472F14.1
glycine dehydrogenase (decarboxylating)
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens
PREY

CLTC

CHC, CHC17, CLH-17, CLTCL2, Hc
clathrin, heavy chain (Hc)
Autophagy Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

Liu R, Zeng LW, Gong R, Yuan F, Shu HB, Li S

Glycine decarboxylase (GLDC) is a key enzyme of glycine cleavage system that converts glycine into one-carbon units. GLDC is commonly up-regulated and plays important roles in many human cancers. Whether and how GLDC is regulated by post-translational modifications is unknown. Here we report that mechanistic target of rapamycin complex 1 (mTORC1) signal inhibits GLDC acetylation at lysine (K) 514 by ... [more]

Nat Commun Jul. 09, 2021; 12(1);4227 [Pubmed: 34244482]

Throughput

  • High Throughput

Curated By

  • BioGRID