BAIT
GLDC
GCE, GCSP, HYGN1, RP11-472F14.1
glycine dehydrogenase (decarboxylating)
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
PPP1R9B
PPP1R6, PPP1R9, SPINO, Spn
protein phosphatase 1, regulatory subunit 9B
GO Process (11)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- RNA splicing [NAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- cellular response to morphine [ISS]
- filopodium assembly [IMP]
- negative regulation of catalytic activity [NAS]
- negative regulation of cell growth [IDA]
- regulation of cell growth by extracellular stimulus [TAS]
- regulation of cell proliferation [NAS]
- regulation of exit from mitosis [NAS]
- regulation of opioid receptor signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.
Glycine decarboxylase (GLDC) is a key enzyme of glycine cleavage system that converts glycine into one-carbon units. GLDC is commonly up-regulated and plays important roles in many human cancers. Whether and how GLDC is regulated by post-translational modifications is unknown. Here we report that mechanistic target of rapamycin complex 1 (mTORC1) signal inhibits GLDC acetylation at lysine (K) 514 by ... [more]
Nat Commun Jul. 09, 2021; 12(1);4227 [Pubmed: 34244482]
Throughput
- High Throughput
Curated By
- BioGRID