An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly.

Swaminathan S, Kiendl F, Koerner R, Lupetti R, Hengst L, Melchior F

The RanGTPase activating protein RanGAP1 has essential functions in both nucleocytoplasmic transport and mitosis. In interphase, a significant fraction of vertebrate SUMO1-modified RanGAP1 forms a stable complex with the nucleoporin RanBP2/Nup358 at nuclear pore complexes. RanBP2 not only acts in the RanGTPase cycle but also is a SUMO1 E3 ligase. Here, we show that RanGAP1 is phosphorylated on residues T409, ... [more]

J Cell Biol Mar. 29, 2004; 164(7);965-71 [Pubmed: 15037602]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

CDK2

Gene Ontology Biological Process

Gene Ontology Molecular Function

cyclin binding [IDA]cyclin-dependent protein serine/threonine kinase activity [IDA, TAS]histone kinase activity [IDA]protein binding [IPI]

Gene Ontology Cellular Component

RANGAP1