BAIT
TOP3B
TOP3B1
topoisomerase (DNA) III beta
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
ABCA7
ABCA-SSN, ABCX
ATP-binding cassette, sub-family A (ABC1), member 7
GO Process (20)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- apolipoprotein A-I-mediated signaling pathway [IDA]
- cholesterol efflux [IDA]
- high-density lipoprotein particle assembly [IDA]
- memory [ISS]
- negative regulation of ATPase activity [IDA]
- negative regulation of amyloid precursor protein biosynthetic process [ISS]
- negative regulation of beta-amyloid formation [ISS]
- peptide cross-linking [ISS]
- phospholipid efflux [IDA]
- phospholipid scrambling [IDA]
- positive regulation of ATPase activity [IDA]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of beta-amyloid clearance [ISS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of engulfment of apoptotic cell [ISS]
- positive regulation of phagocytosis [ISS]
- positive regulation of phospholipid efflux [ISS]
- protein localization to nucleus [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Topoisomerase 3? (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover ... [more]
Nucleic Acids Res Jul. 08, 2022; 50(12);7013-7033 [Pubmed: 35748872]
Throughput
- High Throughput
Curated By
- BioGRID